452 4.3.1 Insufficient system resources
We often see this error from Microsoft Exchange servers, when either the allotted disk space is used up or the entire disk is full.
If you are receiving this error please check that your server has sufficient disk space and this error message should be cleared.
If your Microsoft Exchange server disk space is full, removing email from your mailbox will not immediately free up your disk space problems. When you remove email from your inbox the Exchange server does not immediately delete your mail freeing up space on the actual disk.
To correct this problem you will need to address the disk space shortage by moving mailboxes, purging logs from the disk or removing unused files from your drive.